Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk.
Identifieur interne : 001143 ( Main/Exploration ); précédent : 001142; suivant : 001144Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk.
Auteurs : Brian A. Ference [États-Unis] ; John J P. Kastelein [Pays-Bas] ; Henry N. Ginsberg [États-Unis] ; M John Chapman [France] ; Stephen J. Nicholls [Australie] ; Kausik K. Ray [Royaume-Uni] ; Chris J. Packard [Royaume-Uni] ; Ulrich Laufs [Allemagne] ; Robert D. Brook ; Clare Oliver-Williams [Royaume-Uni] ; Adam S. Butterworth [Royaume-Uni] ; John Danesh [Royaume-Uni] ; George Davey Smith [Royaume-Uni] ; Alberico L. Catapano [Italie] ; Marc S. Sabatine [États-Unis]Source :
- JAMA [ 1538-3598 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse de randomisation mendélienne, Anticholestérolémiants (usage thérapeutique), Apolipoprotéines B (sang), Cholestérol HDL (sang), Cholestérol LDL (sang), Facteurs de risque, Femelle, Humains, Hydroxymethylglutaryl-CoA reductases (génétique), Hypercholestérolémie (génétique), Hypercholestérolémie (sang), Hypercholestérolémie (traitement médicamenteux), Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique), Maladies cardiovasculaires (), Maladies cardiovasculaires (génétique), Mâle, Protéines de transfert des esters de cholestérol (antagonistes et inhibiteurs), Protéines de transfert des esters de cholestérol (génétique), Variation génétique.
- MESH :
- antagonistes et inhibiteurs : Protéines de transfert des esters de cholestérol.
- génétique : Hydroxymethylglutaryl-CoA reductases, Hypercholestérolémie, Maladies cardiovasculaires, Protéines de transfert des esters de cholestérol.
- sang : Apolipoprotéines B, Cholestérol HDL, Cholestérol LDL, Hypercholestérolémie.
- traitement médicamenteux : Hypercholestérolémie.
- usage thérapeutique : Anticholestérolémiants, Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- Adulte d'âge moyen, Analyse de randomisation mendélienne, Facteurs de risque, Femelle, Humains, Maladies cardiovasculaires, Mâle, Variation génétique.
English descriptors
- KwdEn :
- Anticholesteremic Agents (therapeutic use), Apolipoproteins B (blood), Cardiovascular Diseases (genetics), Cardiovascular Diseases (prevention & control), Cholesterol Ester Transfer Proteins (antagonists & inhibitors), Cholesterol Ester Transfer Proteins (genetics), Cholesterol, HDL (blood), Cholesterol, LDL (blood), Female, Genetic Variation, Humans, Hydroxymethylglutaryl CoA Reductases (genetics), Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use), Hypercholesterolemia (blood), Hypercholesterolemia (drug therapy), Hypercholesterolemia (genetics), Male, Mendelian Randomization Analysis, Middle Aged, Risk Factors.
- MESH :
- chemical , antagonists & inhibitors : Cholesterol Ester Transfer Proteins.
- chemical , blood : Apolipoproteins B, Cholesterol, HDL, Cholesterol, LDL.
- chemical , genetics : Cholesterol Ester Transfer Proteins, Hydroxymethylglutaryl CoA Reductases.
- chemical , therapeutic use : Anticholesteremic Agents, Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- blood : Hypercholesterolemia.
- drug therapy : Hypercholesterolemia.
- genetics : Cardiovascular Diseases, Hypercholesterolemia.
- prevention & control : Cardiovascular Diseases.
- Female, Genetic Variation, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Risk Factors.
Abstract
Some cholesteryl ester transfer protein (CETP) inhibitors lower low-density lipoprotein cholesterol (LDL-C) levels without reducing cardiovascular events, suggesting that the clinical benefit of lowering LDL-C may depend on how LDL-C is lowered.
DOI: 10.1001/jama.2017.11467
PubMed: 28846118
Affiliations:
- Allemagne, Australie, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, District de Leipzig, Grand Londres, Hollande-Septentrionale, Massachusetts, Michigan, Saxe (Land), Écosse, État de New York, Île-de-France
- Amsterdam, Cambridge, Glasgow, Leipzig, Londres, Paris
- Université d'Amsterdam, Université de Cambridge, Université de Glasgow
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Le document en format XML
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Ference</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cardiovascular Medicine, Wayne State University School of Medicine, Detroit, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Division of Cardiovascular Medicine, Wayne State University School of Medicine, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name><affiliation wicri:level="4"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Ginsberg, Henry N" sort="Ginsberg, Henry N" uniqKey="Ginsberg H" first="Henry N" last="Ginsberg">Henry N. Ginsberg</name><affiliation wicri:level="2"><nlm:affiliation>Irving Institute for Clinical and Translational Research, Columbia University College of Physicians and Surgeons, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Irving Institute for Clinical and Translational Research, Columbia University College of Physicians and Surgeons, New York</wicri:cityArea></affiliation></author><author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name><affiliation wicri:level="3"><nlm:affiliation>National Institute for Health and Medical Research (INSERM), Pitie-Salpetriere University Hospital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>National Institute for Health and Medical Research (INSERM), Pitie-Salpetriere University Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Nicholls, Stephen J" sort="Nicholls, Stephen J" uniqKey="Nicholls S" first="Stephen J" last="Nicholls">Stephen J. Nicholls</name><affiliation wicri:level="1"><nlm:affiliation>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>South Australian Health and Medical Research Institute, University of Adelaide, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K" last="Ray">Kausik K. Ray</name><affiliation wicri:level="3"><nlm:affiliation>Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Packard, Chris J" sort="Packard, Chris J" uniqKey="Packard C" first="Chris J" last="Packard">Chris J. Packard</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Laufs, Ulrich" sort="Laufs, Ulrich" uniqKey="Laufs U" first="Ulrich" last="Laufs">Ulrich Laufs</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University of Leipzig, Leipzig, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, University of Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Brook, Robert D" sort="Brook, Robert D" uniqKey="Brook R" first="Robert D" last="Brook">Robert D. Brook</name><affiliation><nlm:affiliation>Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor.</nlm:affiliation><wicri:noCountry code="subField">Ann Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Oliver Williams, Clare" sort="Oliver Williams, Clare" uniqKey="Oliver Williams C" first="Clare" last="Oliver-Williams">Clare Oliver-Williams</name><affiliation wicri:level="4"><nlm:affiliation>MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Butterworth, Adam S" sort="Butterworth, Adam S" uniqKey="Butterworth A" first="Adam S" last="Butterworth">Adam S. Butterworth</name><affiliation wicri:level="4"><nlm:affiliation>MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><affiliation wicri:level="4"><nlm:affiliation>MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name><affiliation wicri:level="1"><nlm:affiliation>MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Catapano, Alberico L" sort="Catapano, Alberico L" uniqKey="Catapano A" first="Alberico L" last="Catapano">Alberico L. Catapano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacological and Biomolecular Sciences, University of Milan and Multimedica IRCCS, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmacological and Biomolecular Sciences, University of Milan and Multimedica IRCCS, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name><affiliation wicri:level="2"><nlm:affiliation>Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anticholesteremic Agents (therapeutic use)</term><term>Apolipoproteins B (blood)</term><term>Cardiovascular Diseases (genetics)</term><term>Cardiovascular Diseases (prevention & control)</term><term>Cholesterol Ester Transfer Proteins (antagonists & inhibitors)</term><term>Cholesterol Ester Transfer Proteins (genetics)</term><term>Cholesterol, HDL (blood)</term><term>Cholesterol, LDL (blood)</term><term>Female</term><term>Genetic Variation</term><term>Humans</term><term>Hydroxymethylglutaryl CoA Reductases (genetics)</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term><term>Hypercholesterolemia (blood)</term><term>Hypercholesterolemia (drug therapy)</term><term>Hypercholesterolemia (genetics)</term><term>Male</term><term>Mendelian Randomization Analysis</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de randomisation mendélienne</term><term>Anticholestérolémiants (usage thérapeutique)</term><term>Apolipoprotéines B (sang)</term><term>Cholestérol HDL (sang)</term><term>Cholestérol LDL (sang)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Hydroxymethylglutaryl-CoA reductases (génétique)</term><term>Hypercholestérolémie (génétique)</term><term>Hypercholestérolémie (sang)</term><term>Hypercholestérolémie (traitement médicamenteux)</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique)</term><term>Maladies cardiovasculaires ()</term><term>Maladies cardiovasculaires (génétique)</term><term>Mâle</term><term>Protéines de transfert des esters de cholestérol (antagonistes et inhibiteurs)</term><term>Protéines de transfert des esters de cholestérol (génétique)</term><term>Variation génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Cholesterol Ester Transfer Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Apolipoproteins B</term><term>Cholesterol, HDL</term><term>Cholesterol, LDL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cholesterol Ester Transfer Proteins</term><term>Hydroxymethylglutaryl CoA Reductases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticholesteremic Agents</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines de transfert des esters de cholestérol</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hypercholesterolemia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypercholesterolemia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cardiovascular Diseases</term><term>Hypercholesterolemia</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hydroxymethylglutaryl-CoA reductases</term><term>Hypercholestérolémie</term><term>Maladies cardiovasculaires</term><term>Protéines de transfert des esters de cholestérol</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Apolipoprotéines B</term><term>Cholestérol HDL</term><term>Cholestérol LDL</term><term>Hypercholestérolémie</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hypercholestérolémie</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticholestérolémiants</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Genetic Variation</term><term>Humans</term><term>Male</term><term>Mendelian Randomization Analysis</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de randomisation mendélienne</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Maladies cardiovasculaires</term><term>Mâle</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some cholesteryl ester transfer protein (CETP) inhibitors lower low-density lipoprotein cholesterol (LDL-C) levels without reducing cardiovascular events, suggesting that the clinical benefit of lowering LDL-C may depend on how LDL-C is lowered.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>District de Leipzig</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Massachusetts</li><li>Michigan</li><li>Saxe (Land)</li><li>Écosse</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Cambridge</li><li>Glasgow</li><li>Leipzig</li><li>Londres</li><li>Paris</li></settlement><orgName><li>Université d'Amsterdam</li><li>Université de Cambridge</li><li>Université de Glasgow</li></orgName></list><tree><noCountry><name sortKey="Brook, Robert D" sort="Brook, Robert D" uniqKey="Brook R" first="Robert D" last="Brook">Robert D. Brook</name></noCountry><country name="États-Unis"><region name="Michigan"><name sortKey="Ference, Brian A" sort="Ference, Brian A" uniqKey="Ference B" first="Brian A" last="Ference">Brian A. Ference</name></region><name sortKey="Ginsberg, Henry N" sort="Ginsberg, Henry N" uniqKey="Ginsberg H" first="Henry N" last="Ginsberg">Henry N. Ginsberg</name><name sortKey="Sabatine, Marc S" sort="Sabatine, Marc S" uniqKey="Sabatine M" first="Marc S" last="Sabatine">Marc S. Sabatine</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name></region></country><country name="Australie"><noRegion><name sortKey="Nicholls, Stephen J" sort="Nicholls, Stephen J" uniqKey="Nicholls S" first="Stephen J" last="Nicholls">Stephen J. Nicholls</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K" last="Ray">Kausik K. Ray</name></region><name sortKey="Butterworth, Adam S" sort="Butterworth, Adam S" uniqKey="Butterworth A" first="Adam S" last="Butterworth">Adam S. Butterworth</name><name sortKey="Danesh, John" sort="Danesh, John" uniqKey="Danesh J" first="John" last="Danesh">John Danesh</name><name sortKey="Oliver Williams, Clare" sort="Oliver Williams, Clare" uniqKey="Oliver Williams C" first="Clare" last="Oliver-Williams">Clare Oliver-Williams</name><name sortKey="Packard, Chris J" sort="Packard, Chris J" uniqKey="Packard C" first="Chris J" last="Packard">Chris J. Packard</name><name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name></country><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Laufs, Ulrich" sort="Laufs, Ulrich" uniqKey="Laufs U" first="Ulrich" last="Laufs">Ulrich Laufs</name></region></country><country name="Italie"><noRegion><name sortKey="Catapano, Alberico L" sort="Catapano, Alberico L" uniqKey="Catapano A" first="Alberico L" last="Catapano">Alberico L. Catapano</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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